Salvia divinorum dried leaves
salvia divinorum is a hallucinogen selling over the internet in several forms. Perhaps the most common method of use is smoking the dried leaf material. The sole presumed active constituent, salvinorin A, is a selective kappa-opioid receptor agonist. Upon smoking of the dried leaf material, some of the salvinorin A is destroy or converted to other materials, leaving in question the actual amount of salvinorin A delivered that leads to the psychotomimetic effect. On average, 133 μg of salvinorin A was deliver in the smoke from an 830 mg per cigarette, which contained ∼2.7 mg of salvinorin A. Salvia divinorum dried leaves
Hence, only ∼5% of the salvinorin A available in the dried plant material was delivere in the smoke. Upon smoking, hydrolysis of salvinorin A to salvinorin B, an inactive and minor component of the leaf material. Also occurs as evidenced by a higher delivered amount of salvinorin B vs salvinorin A (217 vs 133 μg per cigarette). Since smoking is an effective means of achieving the hallucinogenic effect and salvinorin A is the presumed sole active ingredient in the plant, the estimated effective dose of salvinorin A by inhalation is <133 μg per person. Considering the reported rapid metabolism of salvinorin A in vivo, the dose reaching the brain would be substantially less.
Salvia divinorum is a perennial plant native to the Mazatec areas of the Sierra Madre Oriental Mountains of Mexico. Its habitat is tropical forests, where it grows between 300 and 800 meters above sea level. It belongs to the lamiaceae family, and is mainly reproduce by cuttings since it rarely produces seeds.
It is known by different names: Ska Pastora, Pastora leaves, Maria Pastora leaves, or simply Salvia. Therefore, it has been use by the Mazatec Indians for purposes of divination. As well as to treat various diseases such as anemia, rheumatism, headache, stomach swelling and diarrhea. Salvia divinorum dried leaves
Salvia divinorum contains a potent psychoactive substance called salvinorin A that produces psychedelic and dissociative effects in very low doses, varying in duration depending on the route of administration, usually lasting between fifteen minutes and two hours. Salvinorin A is the most potent natural psychoactive substance known.
Salvia divinorum is use either orally, chewed, or smoked in the form of extracts.